Depression-Like Behavior in a Dehydroepiandrosterone-Induced Mouse Model of Polycystic Ovary Syndrome
نویسندگان
چکیده
منابع مشابه
Demethylation of LHR in dehydroepiandrosterone-induced mouse model of polycystic ovary syndrome.
The cause of polycystic ovary syndrome (PCOS), a complex endocrine disorder, is unknown, but its familial aggregation implies underlying genetic influences. Hyperandrogenemia is regarded as a major endocrine character of the PCOS. In this study, we employed bisulfite sequencing and bisulfite restriction analysis to investigate the DNA methylation status of LHR, AR, FSHR and H19 in dehydroepiand...
متن کاملP-184: Effects of Licorice Hydroalcoholic Root Extract on Letrozole-Induced Polycystic Ovary Syndrome in Mouse
Background: Polycystic ovary syndrome (PCOS) is multifaceted and includes reproductive, metabolic, and general health disorders, so employing different animal models is needed to study the syndrome. Use of an aromatase inhibitor, letrozole, on adult female rats produces a phenotype remarkably similar to that of PCOS. Licorice has been used in treating women infertility for thousands of years. L...
متن کاملExpression and activity of Rac1 is negatively affected in the dehydroepiandrosterone induced polycystic ovary of mouse
BACKGROUND Polycystic ovarian syndrome (PCOS) is characterized by the presence of multiple follicular cysts, giving rise to infertility due to anovulation. This syndrome affects about 10% of women, worldwide. The exact molecular mechanism leading to PCOS remains obscure. RhoGTPase has been associated with oogenesis, but its role in PCOS remains unexplored. Therefore, we attempted to elucidate t...
متن کاملThe Gut Microbiome Is Altered in a Letrozole-Induced Mouse Model of Polycystic Ovary Syndrome
Women with polycystic ovary syndrome (PCOS) have reproductive and metabolic abnormalities that result in an increased risk of infertility, diabetes and cardiovascular disease. The large intestine contains a complex community of microorganisms (the gut microbiome) that is dysregulated in humans with obesity and type 2 diabetes. Using a letrozole-induced PCOS mouse model, we demonstrated signific...
متن کاملAssessment of growth and metabolism characteristics in offspring of dehydroepiandrosterone-induced polycystic ovary syndrome adults
Polycystic ovary syndrome (PCOS) is a common reproductive disorder that has many characteristic features including hyperandrogenemia, insulin resistance and obesity, which may have significant implications for pregnancy outcomes and long-term health of women. Daughters born to PCOS mothers constitute a high-risk group for metabolic and reproductive derangements, but no report has described pote...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 2016
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod.116.142117